Highway 22 was closed about five miles east of the junction with Highway 18 in Yamhill County Thursday morning after a crash involving two vehicles, ODOT said.
Officials said the crash resulted in serious injuries, but it wasn't clear how many people were hurt.
ODOT said the highway was closed indefinitely and there was no established detour.
Drivers should avoid the area, if possible.
Copyright 2015 KPTV-KPDX Broadcasting Corporation. All rights reserved.